The Antibody Variable Region
The idiotypic region of an antibody is defined as the unique set of antigenic determinants located in its variable region.
The specificity of this region has emerged as a significant area of interest, particularly in:
- Research involving antibody drug pharmacodynamics
- Studies in immunogenicity
- Drug pharmacokinetics.
Accordingly, antibodies specially targeted against the complementarity determining region or CDR region of another antibody, play key roles in conducting this research and in assay development. These antibodies are known as anti-idiotypic antibodies and are particularly useful in their ability to specifically bind one monoclonal antibody drug.
Applications of Anti-Idiotypic Antibodies
The human or humanized nature of the majority of therapeutic monoclonal antibodies is particularly conducive to research with anti-idiotypic antibodies. The ability to readily distinguish between endogenous antibodies in a patient’s blood serum and antibody drugs is critical and made possible through the introduction of anti-idiotype antibodies, which bind the unique idiotopes of each unique antibody drug.
Normally, the high concentration of antibodies found in the serum of a patient receiving a human or humanized antibody drug tends to crowd out the drug of interest, rendering it practically invisible, and thus very challenging to track and analyze. In many cases, the difference in concentration of the antibody drug in comparison to naturally-occurring antibodies is on the scale of millions.
A Leading Provider of Anti-Idiotypic Antibody Production and Development Services
Our ProSci Incorporated team of experts draws on extensive experience in the field to generate anti-idiotypic antibodies with robust sensitivity and specificity to support the drug development research of our clients. ProSci Inc. is prepared to help you meet your assay development challenges with quality products and ease-of-use.
For example, the high sensitivity and specificity of our antibodies allow for superior differentiation supporting the design and development of robust pharmacokinetic, immune response assays. By optimizing the quality of your assays, whether you are in the preclinical or clinical phases of your research, ProSci is well positioned to support all aspects of your procedures and to equip you with the tools to more efficiently reach your research goals.
A leader in its field, ProSci is the best choice for the production of anti-idiotypic antibodies. Our priority is to provide the highest quality monoclonal, polyclonal, and single domain antibody services in the industry. ProSci’s expertise in antibody production, immunochemistry services, and biological research is realized through customizable services, innovative products, competitive pricing, high-quality research tools, and unparalleled technical support. If you are ready to take your research to the next level, ProSci is equipped to support you at every step to maximize your outcomes.